AR, AR gene, AR mutations, Abiraterone, Abiraterone- and Enzalutamide-resistant Prostate Cancer, BET, CDK4/6, CRPC, CX-5461, CX-6258, Enzalutamide, JQ1, Ki67, PARP, PARTICIPANTS, PATIENT, PDX culture system, PDX tissues, PDXs, PIM kinase, Patient, RNA polymerase I, androgen, androgen receptor, antitumour, cancer, cancer cells, castration-resistant prostate cancer, cisplatin, cleaved caspase-3, enzalutamide, ex vivo, galeterone, iBET151, patient, patient-derived xenografts, patients, prostate cancers, ribociclib, talazoparib, tumour