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Paper Details

The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population.
Front Immunol
1
2023
CD4, CD4 T cell subpopulations, CD4 T cells, IBD, IBD genetic variants, IBD risk loci, IL23R regions, STAT3, T helper cell lineage, Th17, chromatin, chromatin landscape, chromatin profiles, cytotoxic pTh17 cells, genes, in-vitro polarized CD4 T cell subpopulations, inflammatory bowel disease, inflammatory bowel diseases, intestinal, intestinal epithelial cell, intestinal inflammation, intronic STAT3 and IL23R regions, pTh17 cells, pTh17-related genes, pathogenic Th17 cells, patients, proinflammatory Th17 cell population, regulatory T cells, risk loci, tissue-derived CD4 T cells
Author NameAffiliation
Tiago da Silva MedinaPrincess Margaret Cancer Centre, University Health Network
Tiago da Silva MedinaInternational Research Center, A.C. Camargo Cancer Center
Alex MurisonPrincess Margaret Cancer Centre, University Health Network
Ankur ChakravarthyPrincess Margaret Cancer Centre, University Health Network
Helen Loo YauPrincess Margaret Cancer Centre, University Health Network
Helen Loo YauUniversity of Toronto
William A FaubionMayo Clinic
Mathieu LupienPrincess Margaret Cancer Centre, University Health Network
Mathieu LupienUniversity of Toronto
Mark S SilverbergMount Sinai Hospital, University of Toronto
Cheryl H ArrowsmithPrincess Margaret Cancer Centre, University Health Network
Cheryl H ArrowsmithUniversity of Toronto
Cheryl H ArrowsmithUniversity of Toronto
Daniel D De CarvalhoPrincess Margaret Cancer Centre, University Health Network
Daniel D De CarvalhoUniversity of Toronto
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