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Paper Details

The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer.
Sci Immunol
73
2022
-primed macrophages, CutC, ICB, IFN, PDAC, Pancreatic ductal adenocarcinoma, TAM, TMAO, TMAO-primed macrophages, activated effector T cell, anti-PD1, anti-Tim3, choline, melanoma, mice, mouse, pancreatic cancer, patients, trimethylamine, trimethylamine -oxide, tumor, tumor-associated macrophage, type I IFN, type I interferon
Author NameAffiliation
Chi V Dangthe Wistar Institute
Chi V DangLudwig Institute for Cancer Research
Chi V Dangthe Wistar Institute
Chi V DangLudwig Institute for Cancer Research
Andrew V Kossenkovthe Wistar Institute
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