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Paper Details

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr<sup>682</sup>-phosphorylated APP βCTF.
Sci Adv
12
2023
(H), -, AD, APP, APP CTF, APP-CTF, Alzheimer, Alzheimer's disease, C, CTF, DS, DS fibroblasts, Down syndrome, Lysosome dysfunction, Tyr, V1 subcomplex, adenosine, amyloid precursor protein, human, human DS fibroblasts, lysosomal vacuolar (H)-adenosine triphosphatase, lysosomes, mice, mouse, phospho, phospho-APP-CTF, v-ATPase, v-ATPase V0a1 subunit cytoplasmic domain
Author NameAffiliation
Hediye Erdjument-BromageNew York University Grossman School of Medicine
Hediye Erdjument-BromageKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine
Thomas A NeubertNew York University Grossman School of Medicine
Thomas A NeubertKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine
Thomas A NeubertNew York University Grossman School of Medicine
Thomas A NeubertKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine
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Release 1.2