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Paper Details

Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
Bioorg Med Chem
6
2021
12, 12-LOX, 2-methoxy phenol, Human, Human platelet 12-(S)-Lipoxygenase, LOX, LOX isozymes, Lox12Slug001, ML355, active, active site, benzothiazole, fatty acid, human, human islets, human pancreatic islets, human platelet, human platelet 12-lipoxygenase, inflammatory injury, naphthyl-benzothiazole, oxygenase, phenyl, platelet, thrombosis
Author NameAffiliation
Jerry L NadlerNew York Medical College
Chakrapani KalyanaramanDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco
Matthew P JacobsonDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco
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Release 1.2