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Paper Details

Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4<sup>+</sup> T cells.
Am J Transplant
3
2022
-, CD4, CD4+, CD4+ T cells, CD45RO, CD45RO+ CD4+ T cell, EC, GITR-L, Galectin-3, Galectin-9, IFN, IL-2, IL-6, L-mevalonate, LGALS3, LGALS9, OX40-L, RNA, TNFSF18, TNFSF4, cholesterol, endothelial cells, immunoregulatory genes, mevalonate, pro-inflammatory genes, simvastatin, statin, statins, transcriptomic, treated, vascular endothelial cells, vehicle-treated EC
CD4-Positive T-Lymphocytes, Cells, Cultured, Endothelial Cells, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Mevalonic Acid, Phenotype, Simvastatin, T-Lymphocytes
Author NameAffiliation
Timna AgurBoston Children's Hospital
Timna AgurHarvard Medical School
Johannes WedelBoston Children's Hospital
Johannes WedelHarvard Medical School
Sayantan BoseBoston Children's Hospital
Sayantan BoseHarvard Medical School
A G Pramoda SahankumariBoston Children's Hospital
Daniel GoodmanBoston Children's Hospital
Sek Won KongBoston Children's Hospital
Sek Won KongHarvard Medical School
Chandra C GhoshBoston Children's Hospital
Chandra C GhoshHarvard Medical School
David M BriscoeBoston Children's Hospital
David M BriscoeHarvard Medical School
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Release 1.2