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Paper Details

Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex.
Nat Cancer
8
2022
ALK, CDK9, E3 ligase, P-TEFb complex, PARP, Poly(ADP-ribose), Poly(ADP-ribose) polymerase, Skp2, Tyr19, anaplastic, anaplastic lymphoma kinase, cancers, human, mice, multiple, ovarian and breast tumors, p-ALK, p-Tyr19, phosphorylated ALK, platinum, polymerase II, positive transcriptional elongation factor b, tumor, tumor biospecimens, tumors, tyrosine
Author NameAffiliation
Zhou JiangThe University of Texas MD Anderson Cancer Center
Anil K SoodThe University of Texas MD Anderson Cancer Center
Anil K SoodCenter for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center
Liuqing YangThe University of Texas MD Anderson Cancer Center
Gabriel N HortobagyiThe University of Texas MD Anderson Cancer Center
Mien-Chie HungThe University of Texas MD Anderson Cancer Center
Mien-Chie HungGraduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University
Mien-Chie HungAsia University
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