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Paper Details

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.
Proc Natl Acad Sci U S A
125
2016
CRISPR, Cas9, LOX, Met298Arg, TAAD, Thoracic aortic aneurysms and dissections, aortic disease, ascending aortic aneurysm, c, clustered regularly interspaced short palindromic repeats, clustered regularly interspaced short palindromic repeats-associated protein-9 nuclease, collagen, elastin, human, human allele, humans, lysyl, lysyl oxidase, lysyl oxidase (LOX) gene, mice, mouse, mouse genome, spontaneous hemorrhage, thoracic aortic aneurysm and dissection, vascular diseases
Author NameAffiliation
Vivian LeeWashington University School of Medicine
Ignaty LeshchinerBrigham and Women's Hospital, MA 02115 Harvard Medical School
Nathan O StitzielWashington University School of Medicine, MO 63110 McDonnell Genome Institute
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Release 1.2