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Paper Details

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.
PLoS One
108
2015
19p13, A928V, IBD, P1104A, RA, SLE, TYK2, TYK2 protein, TYK2 protein-coding variants, TYK2 variants, and I684S, autoimmune diseases, autoimmunity, inflammatory bowel disease, kinase, rheumatoid arthritis, rs12720356, rs34536443, rs35018800, systemic lupus erythematosus, tyrosine
Author NameAffiliation
Dorothée DiogoBrigham and Women's Hospital, Harvard Medical School, Broad Institute, United States of America Partners HealthCare Center for Personalized Genetic Medicine
Lisa BastaracheVanderbilt University
Lisa BastaracheVanderbilt University
Katherine P LiaoBrigham and Women's Hospital, Harvard Medical School
Robert R Graham
Robert R Graham
Robert S FultonThe Genome Institute, Washington University School of Medicine
Robert S FultonThe Genome Institute, Washington University School of Medicine
Jeffrey D GreenbergNew York University Hospital for Joint Diseases
Stephen EyreUniversity of Manchester
John BowesUniversity of Manchester
Jing CuiBrigham and Women's Hospital, Harvard Medical School
Annette T LeeThe Feinstein Institute for Medical Research
Joel M KremerThe Albany Medical College and The Center for Rheumatology
Anne BartonUniversity of Manchester
Marieke J H CoenenRadboud university medical center, Radboud Institute for Health Sciences
Lambertus A KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences
René R P de VriesAcademic Medical Center /University of Amsterdam
Paul P TakAcademic Medical Center /University of Amsterdam
Jakob B A CrusiusVU University Medical Center
Fina A S KurreemanLeiden University Medical Centre
Yukinori OkadaBrigham and Women's Hospital, Harvard Medical School, Broad Institute
Yukinori OkadaBrigham and Women's Hospital, Harvard Medical School, Broad Institute
Eli A StahlBrigham and Women's Hospital, Harvard Medical School, Broad Institute
David E LarsonThe Genome Institute, Washington University School of Medicine
Michelle O'LaughlinThe Genome Institute, Washington University School of Medicine
Catrina FronickThe Genome Institute, Washington University School of Medicine
Lucinda FultonThe Genome Institute, Washington University School of Medicine
Tushar Bhangale
Tushar Bhangale
Ward Ortmann
Ward Ortmann
Vivian S Gainer
Elizabeth W KarlsonBrigham and Women's Hospital, Harvard Medical School
Elizabeth W KarlsonBrigham and Women's Hospital, Harvard Medical School
Isaac S Kohane
Isaac S Kohane
Shawn N Murphy
Shawn N Murphy
Javier MartínInstituto de Parasitologia y Biomedicina Lopez-Neyra
Alexandra ZhernakovaLeiden University Medical Centre, University Medical Center and Groningen University
Lars KlareskogKarolinska Institutet and Karolinska University Hospital Solna
Leonid PadyukovKarolinska Institutet and Karolinska University Hospital Solna
Jane WorthingtonUniversity of Manchester
Elaine R MardisThe Genome Institute, Washington University School of Medicine
Elaine R MardisThe Genome Institute, Washington University School of Medicine
Michael F SeldinOmaha VA and University of Nebraska Medical Center
Michael F SeldinOmaha VA and University of Nebraska Medical Center
Peter K GregersenThe Feinstein Institute for Medical Research
Timothy W Behrens
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