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Paper Details

TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma.
J Exp Clin Cancer Res
9
2020
-resistant cells, AXL, AXL receptors, BYL719, HNSCC, HNSCC cell lines, MAPK, PDX models, PDX tissues, PI3K, RNA, TAM, TAM family receptor tyrosine kinases, TAM family receptors, TAM receptors, TYRO3, alpelisib, cell lines, drug, drug-resistant PDX tissues, drug-resistant cells, drug-resistant models, head and neck squamous cell carcinoma, malignancies, mouse, parental, patient, patients, phosphatidylinositol, phosphatidylinositol 3-kinase, resistant cells, sensitized, xenografts
Animals, Apoptosis, Axl Receptor Tyrosine Kinase, Biomarkers, Tumor, Cell Movement, Cell Proliferation, Class I Phosphatidylinositol 3-Kinases, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Humans, MAP Kinase Signaling System, Mice, Prognosis, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, Squamous Cell Carcinoma of Head and Neck, Survival Rate, Thiazoles, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Author NameAffiliation
Kara M RuicciSchulich School of Medicine & Dentistry, Western University
Kara M RuicciSchulich School of Medicine & Dentistry, Western University
Jalna MeensPrincess Margaret Cancer Centre, University Health Network
Paul PlantingaSchulich School of Medicine & Dentistry, Western University
William StechoSchulich School of Medicine & Dentistry, Western University
Nicole PintoSchulich School of Medicine & Dentistry, Western University
John YooSchulich School of Medicine & Dentistry, Western University
John YooSchulich School of Medicine & Dentistry, Western University
Kevin FungSchulich School of Medicine & Dentistry, Western University
Kevin FungSchulich School of Medicine & Dentistry, Western University
Stephanie Danielle MacNeilSchulich School of Medicine & Dentistry, Western University
Stephanie Danielle MacNeilSchulich School of Medicine & Dentistry, Western University
Joe S MymrykSchulich School of Medicine & Dentistry, Western University
Joe S MymrykSchulich School of Medicine & Dentistry, Western University
Joe S MymrykSchulich School of Medicine & Dentistry, Western University
John W BarrettSchulich School of Medicine & Dentistry, Western University
Christopher J HowlettSchulich School of Medicine & Dentistry, Western University
Paul C BoutrosUniversity of California los angeles
Paul C BoutrosInstitute for Precision Health, University of California los angeles
Paul C BoutrosJonsson Comprehensive Cancer Centre, University of California los angeles
Laurie AillesPrincess Margaret Cancer Centre, University Health Network
Laurie AillesUniversity of Toronto
Anthony C NicholsSchulich School of Medicine & Dentistry, Western University
Anthony C NicholsSchulich School of Medicine & Dentistry, Western University
Anthony C NicholsSchulich School of Medicine & Dentistry, Western University
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