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Paper Details

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Proc Natl Acad Sci U S A
63
2021
A53T, IL-1, NLR, NLRP3, NLRP3 inflammasome, Parkinson's disease, Syn, Syn antibody, TLR2, Toll-like receptor 2, amyloid, amyloid-, anti-Syn antibodies, caspase-1, damaged neurons, fibrillar, hiMG, hiPSC-derived A9-dopaminergic neurons, hiPSC-derived microglia, human, human induced pluripotent stem cell (hiPSC)-derived microglia, human microglia, humanized, interleukin-1, mouse, mutant (A53T) Syn, neurotoxicity, nucleotide, nucleotide-binding oligomerization domain (NOD)-like receptor, of -synuclein, oligomeric, pyrin domain-containing 3, synuclein-antibody
Author NameAffiliation
Dorit TrudlerThe Scripps Research Institute
Dorit TrudlerThe Scripps Research Institute
Dorit TrudlerScintillon Institute
Nima DolatabadiThe Scripps Research Institute
Nima DolatabadiThe Scripps Research Institute
Nima DolatabadiScintillon Institute
Abdullah SultanScintillon Institute
Zhenyu ZhongUniversity of California San Diego School of Medicine
Zhenyu ZhongUniversity of Texas Southwestern Medical Center
Zhenyu ZhongUniversity of California San Diego School of Medicine
Yona LevitesCollege of Medicine, University of Florida
Yona LevitesCenter for Translational Research in Neurodegenerative Disease, University of Florida
Yona LevitesMcKnight Brain Institute, University of Florida
Todd E GoldeCollege of Medicine, University of Florida
Todd E GoldeCenter for Translational Research in Neurodegenerative Disease, University of Florida
Todd E GoldeMcKnight Brain Institute, University of Florida
Nicholas J SchorkTranslational Genomics Research Institute
Nicholas J SchorkUniversity of California San Diego
Nicholas J SchorkUniversity of California San Diego
Nicholas J SchorkThe Scripps Research Institute
Michael KarinUniversity of California San Diego School of Medicine
Michael KarinUniversity of California San Diego School of Medicine
Rajesh AmbasudhanThe Scripps Research Institute
Rajesh AmbasudhanThe Scripps Research Institute
Rajesh AmbasudhanScintillon Institute
Stuart A LiptonThe Scripps Research Institute
Stuart A LiptonThe Scripps Research Institute
Stuart A LiptonScintillon Institute
Stuart A LiptonThe Scripps Research Institute
Stuart A LiptonUniversity of California San Diego School of Medicine
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