Paper Details

Paper Title

Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.

Paper Journal Title

Journal of Medicinal Chemistry

Paper Citation Count

Paper Publication Year

2020

Bio Mention

-, Dihydroisoquinolinone Bicyclic, MLL, MLL-fusion cell lines, MYC, MYC-driven cancer, MYC-driven cancer cells, MYC/WDR5 co-bound genes, WD, WD Repeat Domain 5, WD repeat domain 5, WD40-repeat protein family, WDR5, WDR5 WIN site, WIN site, cancers, chromatin, dihydroisoquinolinone, human

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