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Paper Details

The LINK-A lncRNA interacts with PtdIns(3,4,5)P<sub>3</sub> to hyperactivate AKT and confer resistance to AKT inhibitors.
Nat Cell Biol
187
2017
AKT, LINK, LINK-A, LINK-A PIP3-binding motif, LINK-A lncRNA, PIP3, PIP3-binding lncRNA, Phosphatidylinositol-3,4,5-trisphosphate, PtdIns(3,4,5)P3, RNA, RNAs, breast and lung cancer, breast cancer, breast cancer cells, cancer, cancer cells, lipid-binding long non-coding RNAs, lncRNAs, long intergenic non-coding RNA, long intergenic non-coding RNA for kinase activation, nucleotide, patients, pleckstrin homology domain, rs12095274, single nucleotide polymorphism
Author NameAffiliation
Chen WangSchool of Public Health, Nanjing Medical University
Jun YaoThe University of Texas MD Anderson Cancer Center
Mien-Chie HungThe University of Texas MD Anderson Cancer Center
Mien-Chie HungGraduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University
Mien-Chie HungThe University of Texas MD Anderson Cancer Center
Han LiangThe University of Texas MD Anderson Cancer Center
Han LiangThe University of Texas MD Anderson Cancer Center
Liuqing YangThe University of Texas MD Anderson Cancer Center
Liuqing YangThe University of Texas MD Anderson Cancer Center
Liuqing YangCenter for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center
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