Skip to Main Content

Paper Details

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
EMBO J
32
2022
(, -, GRN, GRN deficiency, GRN-FTLD, Grn, Grn/Trem2 KO, Haploinsufficiency of the progranulin, NfL, PGRN, PGRN)-encoding gene, PGRN-deficient microglia, TDP-43, TREM2, TREM2 antibodies, TREM2 antibody, Trem2, Trem2 deficiency, frontotemporal lobar degeneration, glucose, glucose hypometabolism, human, human-induced pluripotent stem cells, lipid dysregulation, lysosomal deficits, lysosomal dysfunction, macrophages, mice, microglia, microglial hyperactivation, microglial states, neurodegeneration, neurofilament light-chain, neurotoxicity, patients, progranulin, progranulin (PGRN)-encoding gene, progranulin deficiency
Author NameAffiliation
Kathryn M MonroeDenali Therapeutics Inc.
Christian HaassBiomedical Center (BMC), Ludwig-Maximilians-Universitat Munchen
Christian HaassGerman Center for Neurodegenerative Diseases (DZNE) Munich
Christian Haass
Christian HaassBiomedical Center (BMC), Ludwig-Maximilians-Universitat Munchen
Christian HaassGerman Center for Neurodegenerative Diseases (DZNE) Munich
Christian Haass
  • 1 - 7

Datasets

Release 1.2