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Paper Details

Darolutamide and Survival in Metastatic, Hormone-Sensitive Prostate Cancer.
N Engl J Med
293
2022
Darolutamide, Metastatic, Hormone-Sensitive Prostate Cancer, androgen, androgen-receptor, darolutamide, docetaxel, metastatic, hormone-sensitive prostate cancer, neutropenia, nonmetastatic, castration-resistant prostate cancer, patients
Author NameAffiliation
Maha HussainFrom the Massachusetts General Hospital Cancer Center and Harvard Medical School - both in Boston (M.R.S.) the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.) the University of Montreal Hospital Center, Montreal (F.S.) Institut Gustave Roussy, University of Paris-Saclay, France (K.F.) the Englander Institute for Precision Medicine, Meyer Cancer Center, New York-Presbyterian Hospital, New York (C.N.S.) the University of California San Diego School of Medicine, La Jolla (E.D.C.) the Clinical Oncologic Dispensary of Omsk Region, and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) - both in Russia Norton Cancer Institute, KY (C.H.P.) La Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigacion Biomedica de Malaga, and Maimonides Institute for Biomedical Research of Cordoba, Reina Sofia University Hospital, Cordoba (M.J.M.-V.) - both in Spain Fudan University Shanghai Cancer Center, and Liaoning Cancer Hospital and Institute, Shenyang (C.F.) - both in China Ashford Cancer Centre Research, Sao Paulo (F.C.) Tampere University Hospital and Tampere University, Helsinki University Central Hospital, Comprehensive Cancer Center, and Orion Pharma, Espoo (H.J.) - all in Finland Toho University Sakura Medical Center, and Osaka University Hospital, Osaka (M.U.) - both in Japan the Huntsman Cancer Institute, Institut de Recherche Clinique, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain
Fred SaadFrom the Massachusetts General Hospital Cancer Center and Harvard Medical School - both in Boston (M.R.S.) the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.) the University of Montreal Hospital Center, Montreal (F.S.) Institut Gustave Roussy, University of Paris-Saclay, France (K.F.) the Englander Institute for Precision Medicine, Meyer Cancer Center, New York-Presbyterian Hospital, New York (C.N.S.) the University of California San Diego School of Medicine, La Jolla (E.D.C.) the Clinical Oncologic Dispensary of Omsk Region, and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) - both in Russia Norton Cancer Institute, KY (C.H.P.) La Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigacion Biomedica de Malaga, and Maimonides Institute for Biomedical Research of Cordoba, Reina Sofia University Hospital, Cordoba (M.J.M.-V.) - both in Spain Fudan University Shanghai Cancer Center, and Liaoning Cancer Hospital and Institute, Shenyang (C.F.) - both in China Ashford Cancer Centre Research, Sao Paulo (F.C.) Tampere University Hospital and Tampere University, Helsinki University Central Hospital, Comprehensive Cancer Center, and Orion Pharma, Espoo (H.J.) - all in Finland Toho University Sakura Medical Center, and Osaka University Hospital, Osaka (M.U.) - both in Japan the Huntsman Cancer Institute, Institut de Recherche Clinique, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain
Cora N SternbergFrom the Massachusetts General Hospital Cancer Center and Harvard Medical School - both in Boston (M.R.S.) the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.) the University of Montreal Hospital Center, Montreal (F.S.) Institut Gustave Roussy, University of Paris-Saclay, France (K.F.) the Englander Institute for Precision Medicine, Meyer Cancer Center, New York-Presbyterian Hospital, New York (C.N.S.) the University of California San Diego School of Medicine, La Jolla (E.D.C.) the Clinical Oncologic Dispensary of Omsk Region, and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) - both in Russia Norton Cancer Institute, KY (C.H.P.) La Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigacion Biomedica de Malaga, and Maimonides Institute for Biomedical Research of Cordoba, Reina Sofia University Hospital, Cordoba (M.J.M.-V.) - both in Spain Fudan University Shanghai Cancer Center, and Liaoning Cancer Hospital and Institute, Shenyang (C.F.) - both in China Ashford Cancer Centre Research, Sao Paulo (F.C.) Tampere University Hospital and Tampere University, Helsinki University Central Hospital, Comprehensive Cancer Center, and Orion Pharma, Espoo (H.J.) - all in Finland Toho University Sakura Medical Center, and Osaka University Hospital, Osaka (M.U.) - both in Japan the Huntsman Cancer Institute, Institut de Recherche Clinique, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain
Emily D CrawfordFrom the Massachusetts General Hospital Cancer Center and Harvard Medical School - both in Boston (M.R.S.) the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago (M.H.) the University of Montreal Hospital Center, Montreal (F.S.) Institut Gustave Roussy, University of Paris-Saclay, France (K.F.) the Englander Institute for Precision Medicine, Meyer Cancer Center, New York-Presbyterian Hospital, New York (C.N.S.) the University of California San Diego School of Medicine, La Jolla (E.D.C.) the Clinical Oncologic Dispensary of Omsk Region, and P. Hertsen Moscow Oncology Research Institute, Moscow (B.A.) - both in Russia Norton Cancer Institute, KY (C.H.P.) La Unidad de Gestion Clinica Intercentros de Oncologia Medica, Hospitales Universitarios Regional y Virgen Victoria, Instituto de Investigacion Biomedica de Malaga, and Maimonides Institute for Biomedical Research of Cordoba, Reina Sofia University Hospital, Cordoba (M.J.M.-V.) - both in Spain Fudan University Shanghai Cancer Center, and Liaoning Cancer Hospital and Institute, Shenyang (C.F.) - both in China Ashford Cancer Centre Research, Sao Paulo (F.C.) Tampere University Hospital and Tampere University, Helsinki University Central Hospital, Comprehensive Cancer Center, and Orion Pharma, Espoo (H.J.) - all in Finland Toho University Sakura Medical Center, and Osaka University Hospital, Osaka (M.U.) - both in Japan the Huntsman Cancer Institute, Institut de Recherche Clinique, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link