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Paper Details

SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common <i>ALDH2</i> alcohol flushing variant.
Sci Transl Med
12
2023
AKT kinase, ALDH2, CAD, CRISPR-Cas9-corrected iPSC-ECs, EC, EC dysfunction, Endothelial, Endothelial cell, H, NHE-1, NO, Na, Na/H-exchanger 1, SGLT2, SGLT2i, alcohol, alcohol flushing, aldehyde, aldehyde dehydrogenase 2 (), coronary artery disease, eNOS, empagliflozin, endothelial NO synthase, endothelial dysfunction, ethanol, glucose, human, human induced pluripotent stem cell-derived ECs, iPSC-ECs, induced pluripotent stem cell-derived ECs, mice, missense variant, nitric oxide, participants, single-nucleotide polymorphisms, sodium, sodium-glucose cotransporter 2, vascular dysfunction
Author NameAffiliation
Johanne M JustesenStanford University School of Medicine
Manuel A RivasStanford University School of Medicine
Manuel A RivasStanford University School of Medicine
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Release 1.2