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Paper Details

TNF-α modulates genome-wide redistribution of οNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer.
Oncogene
30
2016
AP-1, AP-1 gene, AP-1 motifs, AP-1-, Cancer, HNSCC, HNSCC model, HNSCCs, IL-6, NF-B, NF-B complexes, NF-B-, TP53- or AP-1-, NF-B-specific REs, Np63, SERPINE1, TAp73, TNF, TP53, TP53 and AP-1 motifs, TP53-, TP53-, AP-1- and NF-B-specific REs, TP53/p63 sites, TP63, TP73, UM-SCC46, activator protein-1, cREL, cREL/, cancer, gene network, head and neck squamous cell carcinomas, inflammatory gene signatures, inflammatory genes, luciferase reporter, malignancy, mice, oncogenic gene, p21, p63, p73, promoter, specific sequences, squamous cancer, squamous cancers, target gene, target genes, tumor, tumor necrosis factor
Binding Sites, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Cluster Analysis, Consensus Sequence, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Models, Biological, NF-kappa B, Nucleotide Motifs, Promoter Regions, Genetic, Protein Binding, Protein Transport, Regulatory Sequences, Nucleic Acid, Response Elements, Signal Transduction, Transcription Factor AP-1, Transcription Factors, Transcription Initiation Site, Transcriptional Activation, Tumor Necrosis Factor-alpha, Tumor Protein p73, Tumor Suppressor Protein p53, Tumor Suppressor Proteins
Author NameAffiliation
Han SiNational Institute on Deafness and Other Communication Disorders
Han SiNational Institute on Deafness and Other Communication Disorders
Hai LuNational Institute on Deafness and Other Communication Disorders
Hai LuZhujiang Hospital Guangzhou
Hai LuNational Institute on Deafness and Other Communication Disorders
Hai LuZhujiang Hospital Guangzhou
Xinping YangNational Institute on Deafness and Other Communication Disorders
Xinping YangNational Institute on Deafness and Other Communication Disorders
Austin K MattoxNational Institute on Deafness and Other Communication Disorders
Austin K MattoxNational Institute on Deafness and Other Communication Disorders
Minyoung JangNational Institute on Deafness and Other Communication Disorders
Minyoung JangNational Institute on Deafness and Other Communication Disorders
Yansong BianNational Institute on Deafness and Other Communication Disorders
Yansong BianNational Institute on Deafness and Other Communication Disorders
Emiko SanoUniversity of California
Emiko SanoUniversity of California
Hector ViadiuInstituto de Quimica, Universidad Nacional Autonoma de Mexico (UNAM), Ciudad Universitaria
Hector ViadiuInstituto de Quimica, Universidad Nacional Autonoma de Mexico (UNAM), Ciudad Universitaria
Bin YanThe University of Hong Kong
Bin YanThe University of Hong Kong
Christina YauBuck Institute for Research on Aging
Christina YauBuck Institute for Research on Aging
Sam NgCenter for Biomolecular Sciences and Engineering, University of California
Sam NgCenter for Biomolecular Sciences and Engineering, University of California
Steven K LeeNational Institute on Deafness and Other Communication Disorders
Steven K LeeNational Institute on Deafness and Other Communication Disorders
Rose-Anne RomanoState University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences
Rose-Anne RomanoState University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences
Sean DavisNational Cancer Institute
Susan R DavisNational Cancer Institute
Robert L WalkerNational Cancer Institute
Robert L WalkerNational Cancer Institute
Wenming XiaoNational Center for Toxicological Research
Wenming XiaoNational Center for Toxicological Research
Hao SunNational Institute of Arthritis
Hao SunNational Institute of Arthritis
Lai WeiClinical Immunology Section, National Eye Institute
Lai WeiSun Yat-sen University
Lai WeiClinical Immunology Section, National Eye Institute
Lai WeiSun Yat-sen University
Satrajit SinhaState University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences
Satrajit SinhaState University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences
Christopher C BenzBuck Institute for Research on Aging
Christopher C BenzBuck Institute for Research on Aging
Joshua M StuartCenter for Biomolecular Sciences and Engineering, University of California
Joshua M StuartCenter for Biomolecular Sciences and Engineering, University of California
Paul S MeltzerNational Cancer Institute
Paul S MeltzerNational Cancer Institute
Carter Van WaesNational Institute on Deafness and Other Communication Disorders
Carter Van WaesNational Institute on Deafness and Other Communication Disorders
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