-overexpressing astrocytes, CAG-repeat length, CD44, HD, Huntington disease, astrocyte types, astrocytes, astrocytic and microglial genes, astrocytic and microglial modules, astrogliosis, caudate astrocytes, ceramides, cingulate, cingulate HD astrocytes, consensus gene signature, fatty acid, fatty acids, fibrous, fibrous-like - CD44-positive, astrocytes, gene CAG repeat, genes, glutamate, metallothionein, metallothionein gene locus, metallothionein genes, metallothionein-overexpressing astrocytes, metallothioneins, microglia, neurodegenerative disease, neuronal, neurons, neuroprotective astrocyte state, patient, patient-derived directly reprogrammed HD MSNs, patients, protoplasmic astrocyte, protoplasmic astrocyte cluster, protoplasmic astrocytes, rotenone, single-nucleotide, snRNAseq, striatal medium spiny neurons, vulnerable medium spiny neurons