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Paper Details

Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses.
ACS Chemical Biology
15
2019
/TNF dependent genes, BRD, BRD2, BRD2-deficient, BRD2-deficient keratinocytes, BRD2-deficient primary keratinocytes, BRD3, BRD4, CXC motif chemokines 1/2/6, CXCL1/2/6, Cas9, G-CSF, IL17, IL17A, IL17A producing T-helper 17 cells, IL22, IL8, Interleukin-17A, Keratinocyte, RNA, TNF, autoimmune diseases, bromodomain and extra-terminal domain (BET) family proteins, bromodomain-containing protein 2, genes, granulocyte colony stimulating factor, human, parenchymal cells, primary human epidermal keratinocytes, psoriasis, psoriatic, rheumatoid arthritis, rheumatoid arthritis relevant genes, three-dimensional organotypic raft cultures, tumor necrosis factor
Author NameAffiliation
Charles LuGenomics Research Center , AbbVie Inc.
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Release 1.2