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Paper Details

HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression.
PLoS Genet
67
2018
Brd4, E7, H3K27ac, HPV, HPV-associated cancers, HPV16, amplified cellular sequence, amplified cellular sequences, cellular chromatin, cellular enhancer, chromatin, chromosome 2p23, epithelial-cell-type specific enhancer, flanking cellular DNA, human, human papillomavirus (HPV) genomes, integration locus, intergenic region, oncogene, super-enhancer, super-enhancer-like element, viral E6, viral E6/E7 oncogenes, viral enhancer, viral oncogene, viral oncogenes, viral upstream regulatory region, viral-cellular fusion transcript, viral-cellular super-enhancer
Author NameAffiliation
Haiqing FuNational Cancer Institute, National Institutes of Health
Haiqing FuNational Cancer Institute, National Institutes of Health
Keiko AkagiThe Ohio State University Comprehensive Cancer Center
David E SymerThe Ohio State University Comprehensive Cancer Center
David E SymerThe Ohio State University Comprehensive Cancer Center
David E SymerThe Ohio State University Comprehensive Cancer Center
Mirit I AladjemNational Cancer Institute, National Institutes of Health
Mirit I AladjemNational Cancer Institute, National Institutes of Health
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