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Paper Details

Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.
PLoS Genet
13
2021
AKT, PI3K, PIK3CA, PIK3CA hotspot mutations, PIK3CAH1047R, breast cancer, breast tumors, cancer, hotspot PIK3CA variant, human, human cell model, mTOR, mutant PIK3CA allele, p110, patient, stemness, tumor, tumor samples, tumors
Author NameAffiliation
Oscar M RuedaCancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge
Oscar M RuedaAddenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust
Oscar M RuedaNIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust
Carlos CaldasCancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge
Carlos CaldasAddenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust
Carlos CaldasNIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust
Alex TokerMedicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Robert K SempleQueen's Medical Research Institute, University of Edinburgh
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