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Paper Details

Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Proc Natl Acad Sci U S A
8
2023
15-lipoxygenase, 15LOX, ETE, ETE-PE, FerroLOXIN-1, Ferroptosis, GSH, Glutathione, PE, PEBP1, PEBP1 complex, acute injuries of the brain, anticancer, chronic degenerative diseases, eicosatetraenoyl-PE, ferroptosis, iron, oxygen, phosphatidylethanolamine, phosphatidylethanolamine (PE)-binding protein 1, polyunsaturated PE, thiols
Author NameAffiliation
Simon C WatkinsUniversity of Pittsburgh
Simon C WatkinsUniversity of Pittsburgh
Andrew P VanDemarkUniversity of Pittsburgh
Anton SimeonovNational Center for Advancing Translational Sciences
Ivet BaharLaufer Center for Physical Quantitative Biology and Department of Biochemistry and Cell Biology, Stony Brook University
Valerian E KaganCenter for Free Radical and Antioxidant Health, University of Pittsburgh
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