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Paper Details

Dysregulation of the mevalonate pathway promotes transformation.
Proc Natl Acad Sci U S A
292
2010
HMGCR, MVA, MVA pathway genes, RAS, breast cancer, cancer, cancers, cardiovascular disease, cholesterol, full-length HMGCR, human, hydroxymethylglutaryl coenzyme A, hydroxymethylglutaryl coenzyme A reductase, isoprenoids, mRNA, metabolic oncogene, mevalonate, mice, mouse, patient, primary mouse embryonic fibroblasts cells, statin, transformed, transformed and nontransformed cells
Alternative Splicing, Animals, Base Sequence, Breast Neoplasms, Cell Line, Tumor, Cell Transformation, Neoplastic, DNA Primers, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Hydroxymethylglutaryl CoA Reductases, Male, Mevalonic Acid, Mice, Mice, SCID, Neoplasm Transplantation, RNA, Messenger, RNA, Neoplasm, Transplantation, Heterologous
Author NameAffiliation
James W ClendeningOntario Cancer Institute
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