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Paper Details

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome.
PLoS Genet
37
2021
137 genes, ACE, Alzheimer's, Alzheimer's disease, GPNMB, KCNQ5, Man, Online Mendelian Inheritance in Man, Parkinson's disease, RERE, SUOX, amyotrophic lateral sclerosis, anorexia, bipolar disorder, brain, brain diseases, brain transcriptome, cis-acting brain-derived expression quantitative trait loci, colocalized genes, eQTLs, genes, genomic region, major depressive disorder, monogenic, monogenic disease, multiple sclerosis, neurological and psychiatric disease, neurological and psychiatric diseases, neurological and psychiatric disorders, neuropsychiatric diseases, psychiatric diseases, schizophrenia
Author NameAffiliation
Denis BairdUniversity of Bristol
Solveig K Sieberts
Solveig K Sieberts
Thanneer M Perumal
Minerva M CarrasquilloMayo Clinic Florida
Mariet AllenMayo Clinic Florida
Joseph S ReddyMayo Clinic Florida
Philip L De JagerColumbia University Medical Centre
Philip L De JagerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Centre
Philip L De JagerColumbia University Medical Centre
Philip L De JagerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Centre
Nil??fer Ertekin-TanerMayo Clinic Florida
Nil??fer Ertekin-TanerMayo Clinic Florida
Lara M Mangravite
Lara M Mangravite
Benjamin A Logsdon
Karol Estrada
Karol EstradaBioMarin Pharmaceuticals
Karol Estrada
Karol EstradaBioMarin Pharmaceuticals
George Davey SmithUniversity of Bristol
George Davey SmithNIHR Bristol Biomedical Research Centre, University of Bristol
George Davey SmithUniversity of Bristol
George Davey SmithNIHR Bristol Biomedical Research Centre, University of Bristol
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Datasets

Dataset
Description
Source Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Open Targets PlatformOpen Targets Platform combines and systematically integrates genetics evidence with more than 20 other data sources to provide target-disease associations, prioritised through an integrated score that weighs the evidence from each data source and type.Link
Release 1.2