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Paper Details

EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Nat Cancer
104
2021
CD8+, CD8+ T cells, CPI, EZH2, ISG, ISGs, M1, M1 tumor-associated macrophages, PD-1, PD-L1, Prostate cancers, STING, double-stranded RNA, dsRNA, enhancer of zeste homolog-2, interferon, interferon-stimulated genes, patients, programmed cell death protein 1, prostate cancer, tumor, tumor-associated macrophages, tumors
Author NameAffiliation
Anjali V SheahanDana-Farber Cancer Institute
Sylvan C BacaDana-Farber Cancer Institute
Nadia BoufaiedResearch Institute of the McGill University Health Centre
Huihui YeUniversity of California at Los Angeles
Mark M PomerantzDana-Farber Cancer Institute
Mark M PomerantzDana-Farber Cancer Institute
Adam G SowalskyCenter for Cancer Research, National Cancer Institute, National Institutes of Health
Housheng Hansen HeUniversity of Toronto and Princess Margaret Cancer Center University Health Network
Matthew L FreedmanDana-Farber Cancer Institute
Matthew L FreedmanDana-Farber Cancer Institute
Steven P BalkBeth Israel Deaconess Medical Center and Harvard Medical School
Massimo Loda
Leigh EllisDana-Farber Cancer Institute
Leigh EllisBrigham and Women's Hospital, Harvard Medical School
Leigh EllisThe Broad Institute of MIT and Harvard
Leigh EllisCedars-Sinai Medical Center
Leigh EllisCedars-Sinai Samuel Oschin Comprehensive Cancer Institute
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