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Paper Details

Acquired Resistance to KRAS<sup>G12C</sup> Inhibition in Cancer.
N Engl J Med
425
2021
ALK, BRAF, Cancer, FGFR3, G12D, G13D, H95D, KRAS, KRAS -mutant cancers, KRAS allele, KRAS mutations, KRASG12C, MAP2K1, MET, NF1, NRAS, PTEN, Q61H, R68S, RAF1, RET, V/W,, Y96C, adagrasib, amino acid, appendiceal cancer, cancer, cancers, codon 12, colorectal cancer, cysteine, glycine, lung adenocarcinoma, non-small-cell lung cancer, patients, sotorasib, squamous-cell carcinoma
Author NameAffiliation
Gregory J RielyFrom Dana-Farber Cancer Institute (M.M.A., Massachusetts General Hospital (R.S.H., and Brigham and Women's Hospital (L.M.S., and Broad Institute of MIT and Harvard (S.L., A.J.A.) and Foundation Medicine (J.L., Cambridge - all in Massachusetts Henry Ford Cancer Institute, Detroit (I.I.R.) Memorial Sloan Kettering Cancer Center, P.L.) Chao Family Comprehensive Cancer Center, University of California, J.G.C.) - all in California Sarah Cannon Research Institute, Nashville (M.L.J.) the University of Colorado
David E RootFrom Dana-Farber Cancer Institute (M.M.A., Massachusetts General Hospital (R.S.H., and Brigham and Women's Hospital (L.M.S., and Broad Institute of MIT and Harvard (S.L., A.J.A.) and Foundation Medicine (J.L., Cambridge - all in Massachusetts Henry Ford Cancer Institute, Detroit (I.I.R.) Memorial Sloan Kettering Cancer Center, P.L.) Chao Family Comprehensive Cancer Center, University of California, J.G.C.) - all in California Sarah Cannon Research Institute, Nashville (M.L.J.) the University of Colorado
David E RootFrom Dana-Farber Cancer Institute (M.M.A., Massachusetts General Hospital (R.S.H., and Brigham and Women's Hospital (L.M.S., and Broad Institute of MIT and Harvard (S.L., A.J.A.) and Foundation Medicine (J.L., Cambridge - all in Massachusetts Henry Ford Cancer Institute, Detroit (I.I.R.) Memorial Sloan Kettering Cancer Center, P.L.) Chao Family Comprehensive Cancer Center, University of California, J.G.C.) - all in California Sarah Cannon Research Institute, Nashville (M.L.J.) the University of Colorado
Kavita GargFrom Dana-Farber Cancer Institute (M.M.A., Massachusetts General Hospital (R.S.H., and Brigham and Women's Hospital (L.M.S., and Broad Institute of MIT and Harvard (S.L., A.J.A.) and Foundation Medicine (J.L., Cambridge - all in Massachusetts Henry Ford Cancer Institute, Detroit (I.I.R.) Memorial Sloan Kettering Cancer Center, P.L.) Chao Family Comprehensive Cancer Center, University of California, J.G.C.) - all in California Sarah Cannon Research Institute, Nashville (M.L.J.) the University of Colorado
Pasi A J??nneFrom Dana-Farber Cancer Institute (M.M.A., Massachusetts General Hospital (R.S.H., and Brigham and Women's Hospital (L.M.S., and Broad Institute of MIT and Harvard (S.L., A.J.A.) and Foundation Medicine (J.L., Cambridge - all in Massachusetts Henry Ford Cancer Institute, Detroit (I.I.R.) Memorial Sloan Kettering Cancer Center, P.L.) Chao Family Comprehensive Cancer Center, University of California, J.G.C.) - all in California Sarah Cannon Research Institute, Nashville (M.L.J.) the University of Colorado
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ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link