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Paper Details

Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma.
N Engl J Med
91
2023
IDH, IDH-mutant glioma, IDH-mutant gliomas, IDH1, IDH2 enzymes, INDIGO, Isocitrate, Isocitrate dehydrogenase (IDH, Vorasidenib, alanine, alanine aminotransferase, disability, grade, grade 2, grade 2 IDH-mutant glioma, malignant brain tumors, mutant IDH1, patients, premature death, vorasidenib
Author NameAffiliation
Mehdi TouatFrom Memorial Sloan Kettering Cancer Center, Erasmus MC Cancer Institute, the Netherlands (M.J.B.) Tel Aviv Medical Center, Tel Aviv University, and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) - both in Israel Sorbonne Universite, Institut du Cerveau, Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires la Pitie Salpetriere-Charles Foix, Lyon (F.D.) - both in France Duke University Medical Center, NC (K.B.P.) the University of California, San Francisco (J.C.) Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.) the Royal Marsden Hospital, London (L.W.) Princess Margaret Cancer Centre (W.P.M.), University of Toronto (W.P.M.) - both in Toronto the University of Michigan Comprehensive Cancer Center, Ann Arbor (Y.U.) the University of Alabama at Birmingham, Birmingham (B.N.) Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.H.) Lundin Family Brain Tumor Research Center, University Hospital of Lausanne, and the University of Lausanne - both in Lausanne, Switzerland (A.F.H.) Kyoto University Graduate School of Medicine, Japan (Y.A.) Hospital Universitario 12 de Octubre, Madrid (J.M.S.) Universitatsklinikum Heidelberg and the German Cancer Research Center - both in Heidelberg, Germany (W.W.) the University of Turin, Italy (R.S.) Ohio State University Wexner Medical Center, Columbus (P.G.) Sylvester Comprehensive Cancer Center and the Department of Neurology, University of Miami, Miami (M.F.) University of Texas Southwestern Medical Center, Dallas (E.A.M.) Servier Pharmaceuticals (S.S., I.H.) and Dana-Farber Cancer Institute (P.Y.W.) - both in Boston and the University of California los angeles
Warren P MasonFrom Memorial Sloan Kettering Cancer Center, Erasmus MC Cancer Institute, the Netherlands (M.J.B.) Tel Aviv Medical Center, Tel Aviv University, and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) - both in Israel Sorbonne Universite, Institut du Cerveau, Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires la Pitie Salpetriere-Charles Foix, Lyon (F.D.) - both in France Duke University Medical Center, NC (K.B.P.) the University of California, San Francisco (J.C.) Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.) the Royal Marsden Hospital, London (L.W.) Princess Margaret Cancer Centre (W.P.M.), University of Toronto (W.P.M.) - both in Toronto the University of Michigan Comprehensive Cancer Center, Ann Arbor (Y.U.) the University of Alabama at Birmingham, Birmingham (B.N.) Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.H.) Lundin Family Brain Tumor Research Center, University Hospital of Lausanne, and the University of Lausanne - both in Lausanne, Switzerland (A.F.H.) Kyoto University Graduate School of Medicine, Japan (Y.A.) Hospital Universitario 12 de Octubre, Madrid (J.M.S.) Universitatsklinikum Heidelberg and the German Cancer Research Center - both in Heidelberg, Germany (W.W.) the University of Turin, Italy (R.S.) Ohio State University Wexner Medical Center, Columbus (P.G.) Sylvester Comprehensive Cancer Center and the Department of Neurology, University of Miami, Miami (M.F.) University of Texas Southwestern Medical Center, Dallas (E.A.M.) Servier Pharmaceuticals (S.S., I.H.) and Dana-Farber Cancer Institute (P.Y.W.) - both in Boston and the University of California los angeles
Yoshie UmemuraFrom Memorial Sloan Kettering Cancer Center, Erasmus MC Cancer Institute, the Netherlands (M.J.B.) Tel Aviv Medical Center, Tel Aviv University, and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) - both in Israel Sorbonne Universite, Institut du Cerveau, Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires la Pitie Salpetriere-Charles Foix, Lyon (F.D.) - both in France Duke University Medical Center, NC (K.B.P.) the University of California, San Francisco (J.C.) Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.) the Royal Marsden Hospital, London (L.W.) Princess Margaret Cancer Centre (W.P.M.), University of Toronto (W.P.M.) - both in Toronto the University of Michigan Comprehensive Cancer Center, Ann Arbor (Y.U.) the University of Alabama at Birmingham, Birmingham (B.N.) Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.H.) Lundin Family Brain Tumor Research Center, University Hospital of Lausanne, and the University of Lausanne - both in Lausanne, Switzerland (A.F.H.) Kyoto University Graduate School of Medicine, Japan (Y.A.) Hospital Universitario 12 de Octubre, Madrid (J.M.S.) Universitatsklinikum Heidelberg and the German Cancer Research Center - both in Heidelberg, Germany (W.W.) the University of Turin, Italy (R.S.) Ohio State University Wexner Medical Center, Columbus (P.G.) Sylvester Comprehensive Cancer Center and the Department of Neurology, University of Miami, Miami (M.F.) University of Texas Southwestern Medical Center, Dallas (E.A.M.) Servier Pharmaceuticals (S.S., I.H.) and Dana-Farber Cancer Institute (P.Y.W.) - both in Boston and the University of California los angeles
Patrick Y WenFrom Memorial Sloan Kettering Cancer Center, Erasmus MC Cancer Institute, the Netherlands (M.J.B.) Tel Aviv Medical Center, Tel Aviv University, and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) - both in Israel Sorbonne Universite, Institut du Cerveau, Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires la Pitie Salpetriere-Charles Foix, Lyon (F.D.) - both in France Duke University Medical Center, NC (K.B.P.) the University of California, San Francisco (J.C.) Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.) the Royal Marsden Hospital, London (L.W.) Princess Margaret Cancer Centre (W.P.M.), University of Toronto (W.P.M.) - both in Toronto the University of Michigan Comprehensive Cancer Center, Ann Arbor (Y.U.) the University of Alabama at Birmingham, Birmingham (B.N.) Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.H.) Lundin Family Brain Tumor Research Center, University Hospital of Lausanne, and the University of Lausanne - both in Lausanne, Switzerland (A.F.H.) Kyoto University Graduate School of Medicine, Japan (Y.A.) Hospital Universitario 12 de Octubre, Madrid (J.M.S.) Universitatsklinikum Heidelberg and the German Cancer Research Center - both in Heidelberg, Germany (W.W.) the University of Turin, Italy (R.S.) Ohio State University Wexner Medical Center, Columbus (P.G.) Sylvester Comprehensive Cancer Center and the Department of Neurology, University of Miami, Miami (M.F.) University of Texas Southwestern Medical Center, Dallas (E.A.M.) Servier Pharmaceuticals (S.S., I.H.) and Dana-Farber Cancer Institute (P.Y.W.) - both in Boston and the University of California los angeles
Timothy F CloughesyFrom Memorial Sloan Kettering Cancer Center, Erasmus MC Cancer Institute, the Netherlands (M.J.B.) Tel Aviv Medical Center, Tel Aviv University, and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) - both in Israel Sorbonne Universite, Institut du Cerveau, Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires la Pitie Salpetriere-Charles Foix, Lyon (F.D.) - both in France Duke University Medical Center, NC (K.B.P.) the University of California, San Francisco (J.C.) Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.) the Royal Marsden Hospital, London (L.W.) Princess Margaret Cancer Centre (W.P.M.), University of Toronto (W.P.M.) - both in Toronto the University of Michigan Comprehensive Cancer Center, Ann Arbor (Y.U.) the University of Alabama at Birmingham, Birmingham (B.N.) Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.H.) Lundin Family Brain Tumor Research Center, University Hospital of Lausanne, and the University of Lausanne - both in Lausanne, Switzerland (A.F.H.) Kyoto University Graduate School of Medicine, Japan (Y.A.) Hospital Universitario 12 de Octubre, Madrid (J.M.S.) Universitatsklinikum Heidelberg and the German Cancer Research Center - both in Heidelberg, Germany (W.W.) the University of Turin, Italy (R.S.) Ohio State University Wexner Medical Center, Columbus (P.G.) Sylvester Comprehensive Cancer Center and the Department of Neurology, University of Miami, Miami (M.F.) University of Texas Southwestern Medical Center, Dallas (E.A.M.) Servier Pharmaceuticals (S.S., I.H.) and Dana-Farber Cancer Institute (P.Y.W.) - both in Boston and the University of California los angeles
Timothy F CloughesyFrom Memorial Sloan Kettering Cancer Center, Erasmus MC Cancer Institute, the Netherlands (M.J.B.) Tel Aviv Medical Center, Tel Aviv University, and the Davidoff Cancer Center, Rabin Medical Center, Petah Tikva (S.Y.-K.) - both in Israel Sorbonne Universite, Institut du Cerveau, Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires la Pitie Salpetriere-Charles Foix, Lyon (F.D.) - both in France Duke University Medical Center, NC (K.B.P.) the University of California, San Francisco (J.C.) Huntsman Cancer Institute, University of Utah, Salt Lake City (J.M.) the Royal Marsden Hospital, London (L.W.) Princess Margaret Cancer Centre (W.P.M.), University of Toronto (W.P.M.) - both in Toronto the University of Michigan Comprehensive Cancer Center, Ann Arbor (Y.U.) the University of Alabama at Birmingham, Birmingham (B.N.) Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.H.) Lundin Family Brain Tumor Research Center, University Hospital of Lausanne, and the University of Lausanne - both in Lausanne, Switzerland (A.F.H.) Kyoto University Graduate School of Medicine, Japan (Y.A.) Hospital Universitario 12 de Octubre, Madrid (J.M.S.) Universitatsklinikum Heidelberg and the German Cancer Research Center - both in Heidelberg, Germany (W.W.) the University of Turin, Italy (R.S.) Ohio State University Wexner Medical Center, Columbus (P.G.) Sylvester Comprehensive Cancer Center and the Department of Neurology, University of Miami, Miami (M.F.) University of Texas Southwestern Medical Center, Dallas (E.A.M.) Servier Pharmaceuticals (S.S., I.H.) and Dana-Farber Cancer Institute (P.Y.W.) - both in Boston and the University of California los angeles
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Datasets

Dataset
Description
Source Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
Release 1.2