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| William T Abraham | is Chair of Excellence in Cardiovascular Medicine and Chief of Cardiovascular Medicine at the Ohio State University College of Medicine. He leads MD2K's congestive heart failure studies. |
| Deborah Estrin | professor of public health at Weill Cornell Medical College |
| James M Rehg | is a professor in the School of Interactive Computing at the Georgia Institute of Technology. He is deputy director of MD2K and leads MD2K's data science research. |
| Ida Sim | is a professor of medicine and co-director of biomedical informatics at the University of California san francisco |