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Paper Details

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.
Emerg Microbes Infect
164
2021
3C-like protease, 3CLpro, COVID-19, IRF-3, IRF3, NLRP12, NLRP12 homologs, NSP3, NSP5, NSP5 proteases of, NSP5/3C-like, PLpro, SARS-, SARS-CoV-2, SARS-CoV-2 proteases, TAB1, Type-I IFN, cats, cognate cleavage, mouse, papain, papain-like protease, patients, tigers
Author NameAffiliation
Sarah van TolInstitute for Human Infections and Immunity, The University of Texas Medical Branch
Alexander N FreibergInstitute for Human Infections and Immunity, The University of Texas Medical Branch
Benhur LeeIcahn School of Medicine at Mount Sinai
Benhur LeeIcahn School of Medicine at Mount Sinai
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