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Paper Details

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Proc Natl Acad Sci U S A
323
2018
-, AIM2 inflammasomes, ASC, ATPase, CAPS, IL-1, IL-1 precursor, IL-18, IkB kinase, LPS, LPS-stimulated human blood-derived macrophages, NF-B, NLRC4, NLRP3, NLRP3 inflammasome, OLT1177, caspase-1, cryopyrin, cryopyrin-associated periodic syndrome, freshly, human, human blood neutrophils, humans, inflammation, inflammatory diseases, mice, monocytes, patients, potassium, recombinant NLRP3, spleen cells, stimulated human blood-derived macrophages, sulfonyl nitrile
Author NameAffiliation
Fabia GamboniUniversity of Colorado Denver
Travis NemkovUniversity of Colorado Health Sciences Center
Travis NemkovUniversity of Colorado Health Sciences Center
Angelo D'AlessandroUniversity of Colorado Health Sciences Center
Angelo D'AlessandroUniversity of Colorado Health Sciences Center
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