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Paper Details

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.
5
2023
ACE2, COVID, COVID-19, Host Phosphoinositol-5 Kinase, Human, Human Neurons, PIK5K, Phosphoinositol, SARS, SARS-, SARS-CoV, SARS-CoV-2, TMPRSS2, anatomical abnormalities, angiotensin-converting enzyme 2, apilimod, astrocytes, brain cells, camostat, cathepsin L, cellular serine proteases, coronavirus disease, cytoplasm, double-stranded RNA, encephalopathy, endosomes, headache, human, human iPSC-derived neural cell model, human induced pluripotent stem cell (iPSC)-derived neurons, human neurons, impairment of memory, infected cells, nafamostat, neurological, neurological symptoms, neurons, patients, phosphatidyl-inositol, phosphatidyl-inositol 5 kinase, respiratory illness, seizures, serine, severe acute respiratory syndrome coronavirus, target cell, transmembrane serine protease 2, viral RNA, viral genome, viral late genes, viral surface spike protein
Author NameAffiliation
Markku LaaksoUniversity of Eastern Finland
Johanna KuusistoUniversity of Eastern Finland
Johanna KuusistoDepartment of Medicine and Clinical Research, Kuopio University Hospital
Olli PietiläinenUniversity of Helsinki
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