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Paper Title
The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.
PubMed
Paper Journal Title
J Clin Invest
Paper Citation Count
24
Paper Publication Year
2021
Bio Mention
CVD, ER chaperones, ER stress, ERSD, GRP78, GRP94, Gln152His, Gln152His variation, PCSK9, PCSK9 variant, PCSK9Q152H, PCSK9Q152H variant, PCSK9Q152H variation, cardiovascular disease, cholesterol, hypocholesterolemia, liver hepatocytes, liver injury, low-density lipoprotein, mice, mouse, patients, proPCSK9, proprotein convertase subtilisin/kexin type 9
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Author Name
Affiliation
Guillaume Paré
Population Health Research Institute and Departments of Medicine, McMaster University
Renata Pasqualini
Wadih Arap
Rutgers New Jersey Medical School and Rutgers Cancer Institute of New Jersey
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