), -catenin, AKT, AXIN2, Axin2, Cancer, E545K, H1047R, H1047R tumors, HER-2, HGF, Her-2, Hgf, IGF, IGF-1R, IGF1, Igf-1R, Igf-2, MMTV, MMTV-Her-2 transgenic mouse mammary tumors, MTOR, Mammary tumors, PI3K, PIK3CA, PIK3CA tumors, PIK3CA-H1047R, PIK3CA-H1047R overexpressing human HS578T breast cancer cells, PIK3CA-H1047R- and the -E545K hotspot-mutant genes, PIK3CA-mutant breast cancer, PIK3CA-mutant tumors, PIK3CA-wild-type and HER-2+ breast carcinomas, STAT3, Stat3, WNT, Wnt, breast cancer, cell lines, hepatocyte growth factor, human, insulin-like growth factor 2, mice, mouse, mutant PIK3CA, phosphoinositide 3-kinase catalytic subunit, tumor, tumors