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Paper Details

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression.
N Engl J Med
210
2022
Major Depression, Psilocybin, depression, dizziness, headache, nausea, participants, psilocybin
Author NameAffiliation
David PrintzInstitute of Psychiatry, King's College London (C. Bird, the National Institute for Health and Care Research Clinical Research Facility, King's College Hospital NHS Foundation Trust (K.C.-C., and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital (L.A.J., Tyne and Wear Foundation Trust and Newcastle University, Newcastle (M.W.) - all in the United Kingdom the Institute for Advanced Diagnostics and Therapeutics, S. Rudow) Sant Joan de Deu Hospital and the Sant Joan de Deu Research Foundation, Barcelona (O.A.) SUNY Downstate College of Medicine (P.C.A.), the New York State Psychiatric Institute (D.J.H., Columbia University (D.J.H., Tallaght University Hospital, University Medical Center (UMC) Utrecht Brain Center, University Medical Center Utrecht, University of California San Diego (D.B., and Kadima Neuropsychiatry Institute (D.F., the Weill Institute for Neurosciences, University of California San Francisco, Stanford University, Emory University School of Medicine, T.M.-C.) the Campbell Family Mental Health Research Institute, University of Toronto, Aalborg University Hospital, Aalborg University, R.E.N.) the National Institute of Mental Health, Czech Republic (T.P.) Charite-Universitatsmedizin Berlin, Berlin (D.R.) Duke University School of Medicine, NC (A.J.R.) and the University of Texas (UT) Harris County Psychiatric Center and the UT Center of Excellence on Mood Disorders, UT Houston Medical School
Jair C SoaresInstitute of Psychiatry, King's College London (C. Bird, the National Institute for Health and Care Research Clinical Research Facility, King's College Hospital NHS Foundation Trust (K.C.-C., and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital (L.A.J., Tyne and Wear Foundation Trust and Newcastle University, Newcastle (M.W.) - all in the United Kingdom the Institute for Advanced Diagnostics and Therapeutics, S. Rudow) Sant Joan de Deu Hospital and the Sant Joan de Deu Research Foundation, Barcelona (O.A.) SUNY Downstate College of Medicine (P.C.A.), the New York State Psychiatric Institute (D.J.H., Columbia University (D.J.H., Tallaght University Hospital, University Medical Center (UMC) Utrecht Brain Center, University Medical Center Utrecht, University of California San Diego (D.B., and Kadima Neuropsychiatry Institute (D.F., the Weill Institute for Neurosciences, University of California San Francisco, Stanford University, Emory University School of Medicine, T.M.-C.) the Campbell Family Mental Health Research Institute, University of Toronto, Aalborg University Hospital, Aalborg University, R.E.N.) the National Institute of Mental Health, Czech Republic (T.P.) Charite-Universitatsmedizin Berlin, Berlin (D.R.) Duke University School of Medicine, NC (A.J.R.) and the University of Texas (UT) Harris County Psychiatric Center and the UT Center of Excellence on Mood Disorders, UT Houston Medical School
Allan H YoungInstitute of Psychiatry, King's College London (C. Bird, the National Institute for Health and Care Research Clinical Research Facility, King's College Hospital NHS Foundation Trust (K.C.-C., and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital (L.A.J., Tyne and Wear Foundation Trust and Newcastle University, Newcastle (M.W.) - all in the United Kingdom the Institute for Advanced Diagnostics and Therapeutics, S. Rudow) Sant Joan de Deu Hospital and the Sant Joan de Deu Research Foundation, Barcelona (O.A.) SUNY Downstate College of Medicine (P.C.A.), the New York State Psychiatric Institute (D.J.H., Columbia University (D.J.H., Tallaght University Hospital, University Medical Center (UMC) Utrecht Brain Center, University Medical Center Utrecht, University of California San Diego (D.B., and Kadima Neuropsychiatry Institute (D.F., the Weill Institute for Neurosciences, University of California San Francisco, Stanford University, Emory University School of Medicine, T.M.-C.) the Campbell Family Mental Health Research Institute, University of Toronto, Aalborg University Hospital, Aalborg University, R.E.N.) the National Institute of Mental Health, Czech Republic (T.P.) Charite-Universitatsmedizin Berlin, Berlin (D.R.) Duke University School of Medicine, NC (A.J.R.) and the University of Texas (UT) Harris County Psychiatric Center and the UT Center of Excellence on Mood Disorders, UT Houston Medical School
Allan H YoungInstitute of Psychiatry, King's College London (C. Bird, the National Institute for Health and Care Research Clinical Research Facility, King's College Hospital NHS Foundation Trust (K.C.-C., and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital (L.A.J., Tyne and Wear Foundation Trust and Newcastle University, Newcastle (M.W.) - all in the United Kingdom the Institute for Advanced Diagnostics and Therapeutics, S. Rudow) Sant Joan de Deu Hospital and the Sant Joan de Deu Research Foundation, Barcelona (O.A.) SUNY Downstate College of Medicine (P.C.A.), the New York State Psychiatric Institute (D.J.H., Columbia University (D.J.H., Tallaght University Hospital, University Medical Center (UMC) Utrecht Brain Center, University Medical Center Utrecht, University of California San Diego (D.B., and Kadima Neuropsychiatry Institute (D.F., the Weill Institute for Neurosciences, University of California San Francisco, Stanford University, Emory University School of Medicine, T.M.-C.) the Campbell Family Mental Health Research Institute, University of Toronto, Aalborg University Hospital, Aalborg University, R.E.N.) the National Institute of Mental Health, Czech Republic (T.P.) Charite-Universitatsmedizin Berlin, Berlin (D.R.) Duke University School of Medicine, NC (A.J.R.) and the University of Texas (UT) Harris County Psychiatric Center and the UT Center of Excellence on Mood Disorders, UT Houston Medical School
Sidney ZisookInstitute of Psychiatry, King's College London (C. Bird, the National Institute for Health and Care Research Clinical Research Facility, King's College Hospital NHS Foundation Trust (K.C.-C., and South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital (L.A.J., Tyne and Wear Foundation Trust and Newcastle University, Newcastle (M.W.) - all in the United Kingdom the Institute for Advanced Diagnostics and Therapeutics, S. Rudow) Sant Joan de Deu Hospital and the Sant Joan de Deu Research Foundation, Barcelona (O.A.) SUNY Downstate College of Medicine (P.C.A.), the New York State Psychiatric Institute (D.J.H., Columbia University (D.J.H., Tallaght University Hospital, University Medical Center (UMC) Utrecht Brain Center, University Medical Center Utrecht, University of California San Diego (D.B., and Kadima Neuropsychiatry Institute (D.F., the Weill Institute for Neurosciences, University of California San Francisco, Stanford University, Emory University School of Medicine, T.M.-C.) the Campbell Family Mental Health Research Institute, University of Toronto, Aalborg University Hospital, Aalborg University, R.E.N.) the National Institute of Mental Health, Czech Republic (T.P.) Charite-Universitatsmedizin Berlin, Berlin (D.R.) Duke University School of Medicine, NC (A.J.R.) and the University of Texas (UT) Harris County Psychiatric Center and the UT Center of Excellence on Mood Disorders, UT Houston Medical School
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link