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Paper Details

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
Cancer Discov
11
2020
AML, BET, CDK7, CH3-THF, Folate, H3K27, MTHFR, MYC, SPI1, acute myeloid leukemia, amino acid, anticancer, cancer, cell lines, deficiency of the rate-limiting folate cycle enzyme MTHFR, folate, mouse, patients, primary patient samples
Animals, Clustered Regularly Interspaced Short Palindromic Repeats, Drug Resistance, Neoplasm, Folic Acid, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2), Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Molecular Targeted Therapy, Neoplasms, Proto-Oncogene Proteins c-myc, U937 Cells
Author NameAffiliation
Angela SuINSERM UMR , St Louis Hospital, University of Paris
Frank LingINSERM UMR , St Louis Hospital, University of Paris
Camille VaganayINSERM UMR , St Louis Hospital, University of Paris
Gaetano SodaroINSERM UMR , St Louis Hospital, University of Paris
Cha??ma BenaksasINSERM UMR , St Louis Hospital, University of Paris
Reinaldo Dal BelloINSERM UMR , St Louis Hospital, University of Paris
Antoine Forget (CM4AI)INSERM UMR , St Louis Hospital, University of Paris
Bryann PardieuINSERM UMR , St Louis Hospital, University of Paris
Kevin H LinDuke University
Justine C RutterDuke University
Christopher F BassilDuke University
Gael FortinINSERM UMR , St Louis Hospital, University of Paris
Justine PasanisiINSERM UMR , St Louis Hospital, University of Paris
Il??ana Antony-Debr??INSERM UMR 7, Gustave Roussy Institute, Universite Paris-Saclay
Gabriela AlexeDana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School
Gabriela AlexeThe Broad Institute of Harvard University and Massachusetts Institute of Technology
Gabriela AlexeDana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School
Gabriela AlexeThe Broad Institute of Harvard University and Massachusetts Institute of Technology
Jean-Fran??ois BenoistRobert Debre Hospital
Alain PruvostParis-Saclay University
Yana PikmanDana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School
Yana PikmanDana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School
Jun QiThe Broad Institute of Harvard University and Massachusetts Institute of Technology
Jun QiDana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School
Marie-H??l??ne SchlageterSt Louis Hospital
Marie-H??l??ne SchlageterINSERM U 1, St Louis Hospital, University of Paris
Jean-Baptiste MicolINSERM UMR 7, Gustave Roussy Institute, Universite Paris-Saclay
Jean-Baptiste MicolGustave Roussy Institute
Giovanni RotiUniversity of Parma
Thomas CluzeauCentre Hospitalier Universitaire
Herv?? DombretSt Louis Hospital
Claude Preudhomme
Nina FenouilleINSERM UMR , St Louis Hospital, University of Paris
Lina BenajibaINSERM UMR , St Louis Hospital, University of Paris
Lina BenajibaSt Louis Hospital
Hava M GolanZlotowski Center for Neuroscience, Ben-Gurion University of the Negev
Kimberly StegmaierDana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School
Kimberly StegmaierThe Broad Institute of Harvard University and Massachusetts Institute of Technology
Kimberly StegmaierDana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School
Kimberly StegmaierThe Broad Institute of Harvard University and Massachusetts Institute of Technology
Camille LobryINSERM UMR 7, Gustave Roussy Institute, Universite Paris-Saclay
Kris C WoodDuke University
Raphael ItzyksonINSERM UMR , St Louis Hospital, University of Paris
Alexandre PuissantINSERM UMR , St Louis Hospital, University of Paris
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Release 1.2