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Paper Details

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
Nature
254
2018
73 genes, BRCA1, BRCA1- and BRCA2-deficient cells, BRCA2, CRISPR, DNA lesions, PARP, PARP1, RNASEH2B, cancer, clustered regularly interspersed palindromic repeats, deficiencies in homologous recombination1, deficient in ribonuclease H2, genome, lymphocytic leukaemia, metastatic prostate cancer, olaparib, poly(ADP-ribose), poly(ADP-ribose) polymerase, ribonuclease H2, ribonucleotide, ribonucleotides, topoisomerase 1
Author NameAffiliation
Wei YuanThe Institute of Cancer Research
Matthew ClarkeThe Institute of Cancer Research
Maryou B LambrosThe Institute of Cancer Research
Stephane AngersDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy & Department of Biochemistry, University of Toronto
Jason MoffatUniversity of Toronto
Jason MoffatUniversity of Toronto
Jason MoffatCanadian Institute for Advanced Research
Traver HartThe University of Texas MD Anderson Cancer Center
Johann S de BonoThe Institute of Cancer Research
Johann S de BonoRoyal Marsden NHS Foundation Trust
Andrew P JacksonInstitute of Genetics and Molecular Medicine, University of Edinburgh
Andrew P JacksonInstitute of Genetics and Molecular Medicine, University of Edinburgh
Daniel DurocherThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Daniel DurocherUniversity of Toronto
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