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Paper Details

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.
Neurobiol Dis
89
2017
3-PPP, Ca2+, HD, Huntington disease, MSNs, Pridopidine, Q175KI, S1R, YAC128, YAC128 MSNs, YAC128 co-cultures, YAC128 corticostriatal co-culture model, YAC128 transgenic, aged corticostriatal co-cultures, aging, autosomal dominant disease, calbindin, calcium, calcium signaling genes, corticostriatal synaptic dysfunction, dendritic MSN, dopamine, homer1a, mice, mouse, neurodegeneration of, patients, pridopidine, sigma-1 receptor, spines, striatal, tri, tri-nucleotide repeat
Author NameAffiliation
Rebecca KuskoImmuneering Corporation
Michael R HaydenTeva Pharmaceutical Industries
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Release 1.2