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Paper Details

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis <i>in vivo</i>.
bioRxiv
1
2023
ADP, ADP-ribosylhydrolase, Mac1, Mac1 domain, N40D, NSP3, SARS-CoV, SARS-CoV-2, SARS-CoV-2 NSP3, alanine, amino acid, asparagine, aspartic acid, bacterial and mammalian cells, human, immortalized cell lines, interferon, lung pathology, macrodomain, macrodomain 1, mice, ribosylhydrolase, wildtype
Author NameAffiliation
Taha Y TahaGladstone Institutes
Rahul K SuryawanshiGladstone Institutes
Irene P ChenGladstone Institutes
Irene P ChenUniversity of California San Francisco
Galen J CorreyUniversity of California San Francisco
Galen J CorreyUniversity of California San Francisco
Patrick C O'LearyUniversity of California San Francisco
Manasi P JogalekarUniversity of California San Francisco
Maria McCavitt-MalvidoGladstone Institutes
Morgan E DiolaitiUniversity of California San Francisco
Gabriella R KimmerlyGladstone Institutes
Chia-Lin TsouGladstone Institutes
Luis Martinez-SobridoTexas Biomedical Research Institute
Nevan J Krogan (CM4AI)University of California San Francisco
Alan AshworthUniversity of California San Francisco
James S FraserUniversity of California San Francisco
James S FraserUniversity of California San Francisco
Melanie OttGladstone Institutes
Melanie OttUniversity of California San Francisco
Melanie Ott
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