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Paper Details

Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem
24
2021
BRD0639, MTAP, MTAP-deleted cancer cells, PBM, PRMT5, PRMT5 binding motif, PRMT5 substrates, PRMT5-, RIOK1, Riok1, SAPs, cancer, cells, cysteine, halogenated pyridazinone, histone
Author NameAffiliation
Brian J McMillanCenter for the Development of Therapeutics, The Broad Institute of MIT and Harvard
David E TimmUniversity of Utah
Virendar K KaushikCenter for the Development of Therapeutics, The Broad Institute of MIT and Harvard
William R SellersThe Broad Institute of MIT and Harvard
William R SellersDana-Farber Cancer Institute, Harvard Medical School
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Release 1.2