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Paper Details

(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
Cancer Discov
7
2023
(R)-2-Hydroxyglutarate, (R)-2-hydroxyglutarate, (R)-2HG, 2-oxoglutarate, 2OG, AML, Histone Lysine Demethylases, IDH, IDH-Mutant, IDH-Mutant Cancers, IDH-mutant AML, IDH-mutant cancers, IDH-mutant cells, IDH1, IDH2, KDM5, KDM5 histone lysine demethylases, Lysine, Mutant IDH, Mutant IDH enzymes, TET2, acute myeloid leukemia, cancers, glioma, histone, histone lysine, isocitrate, isocitrate dehydrogenase 1, lysine, mutant IDH, myeloid tumor
Author NameAffiliation
John G DoenchBroad Institute of MIT and Harvard
Keith L LigonBroad Institute of MIT and Harvard
Keith L LigonDana-Farber Cancer Institute
Keith L LigonBoston Children's Hospital and Brigham and Women's Hospital
Lucy A GodleyUniversity of Chicago
Lucy A GodleyUniversity of Chicago
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