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Paper Details

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.
J Alzheimers Dis
48
2019
AD, ATP, ATP synthase, Alzheimer's disease, ApoE4, Apolipoprotein (apo) E4, Apolipoprotein E4, NAD+, NADH, Neuro-2a neuronal cells, Neuronal, apoE, apoE3, apoE3-expressing neurons, apoE4, apoE4 cells, apoE4-expressing neurons, calcium, cytosol, mitochondrial ribosomal proteins, neurons, neurotoxicity, oxygen
Adenosine Triphosphate, Animals, Apolipoprotein E4, Cell Line, Tumor, Energy Metabolism, Mice, Mitochondria, NAD, Neurons, Proteome, Reactive Oxygen Species, Stress, Physiological, Transcriptome
Author NameAffiliation
Adam L OrrGladstone Institute of Neurological Disease
Adam L OrrPresent address: Helen & Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute
Chaeyoung KimGladstone Institute of Neurological Disease
David Jimenez-MoralesGladstone Institute of Data Science and Biotechnology
David Jimenez-MoralesUniversity of California san francisco
David Jimenez-MoralesStanford University
Billy W NewtonUniversity of California san francisco
Jeffrey R JohnsonGladstone Institute of Data Science and Biotechnology
Jeffrey R JohnsonUniversity of California san francisco
Nevan J Krogan (CM4AI)Gladstone Institute of Data Science and Biotechnology
Nevan J Krogan (CM4AI)Quantitative Biosciences Institute, University of California san francisco
Nevan J Krogan (CM4AI)University of California san francisco
Danielle L SwaneyGladstone Institute of Data Science and Biotechnology
Danielle L SwaneyUniversity of California san francisco
Robert W MahleyGladstone Institute of Neurological Disease
Robert W MahleyUniversity of California san francisco
Robert W MahleyGladstone Institute of Neurological Disease
Robert W MahleyUniversity of California san francisco
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