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Paper Details

Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover.
Diabetologia
2
2023
ATP, Allele-edited single-cell clones, BODIPY, C, C allele, C-allele, C/, C/C adipocytes, Cas9, Gly482Gly, Gly482Ser, PGC-1, PGC-1 protein, PPARGC1A, PPARGC1A mRNA, PPARGC1A rs8192678, Ser482Ser, T, T/T, adipocyte biology, adipocyte phenotype, adipogenic, allele, genes, human, human pre-adipocyte white adipose tissue (hWAs) cell line, human white adipocyte, human white adipose cells, isogenic, metabolic disorders, obesity, oxygen, peroxisome proliferator-activated receptor coactivator 1-, rs8192678, rs8192678 variant, triacylglycerol, white adipocyte
Author NameAffiliation
Melina ClaussnitzerBroad Institute of MIT and Harvard
Melina ClaussnitzerBroad Institute of MIT and Harvard
Paul W FranksClinical Research Centre, Lund University
Paul W FranksHarvard T.H. Chan School of Public Health
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