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Paper Details

Adaptive Randomization of Neratinib in Early Breast Cancer.
N Engl J Med
248
2016
70-gene profile, Early Breast Cancer, HER2, HER2-positive, hormone-receptor-negative breast cancer, HER2-positive, hormone-receptor-negative cancer, Neratinib, biomarker, breast cancer, cancer in the, human epidermal growth factor receptor 2, neratinib, patient, patients, trastuzumab, tyrosine, tyrosine kinase, women
Author NameAffiliation
Minetta C LiuFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Christina YauFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Christina YauFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Laura J Van't VeerFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
William F SymmansFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Melissa PaoloniFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Melissa PaoloniFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Michael HogarthFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Judy C BougheyFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Claudine IsaacsFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Rita NandaFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Lajos PusztaiFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Richard B SchwabFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Teresa HelstenFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
Donald A BerryFrom University of California, Buck Institute for Research and Aging, University of California, and University of Southern California, Los Angeles (D.T.) - all in California Georgetown Lombardi Comprehensive Cancer Center, C.I.) University of Minnesota, and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota M.D. Anderson Cancer Center, University of Texas Southwestern Medical Center, MI (J.P.) University of Pennsylvania, Philadelphia (A.D.) Oregon Health and Sciences University, K.A.K.) Swedish Medical Center, Seattle (H.G.K.) University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago Inova Fairfax Hospital, VA (K.K.E.) University of Denver, Denver (A.D.E.) Mayo Clinic, and University of Arizona, R.K.V.) - both in Arizona University of Kansas, Lawrence (Q.J.K.) and Emory University
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link