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Paper Details

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.
Mol Psychiatry
48
2019
AD-type cerebral A amyloidosis, APP, APPKM670, APPKM670/671NL, Alzheimer's disease, C1qa, C1qb, C1qc, Clec7a, Cst7, DAM, DAP12, Itgax, LOAD, PSEN1, PSEN1exon9, TREM2, TYROBP, Trem2, amyloidosis, cerebral A amyloidosis, deficiency of TYROBP, disease, disease-associated microglia, gene network, genes, homeostatic microglia, human, key driver gene, mice, microglial transmembrane signaling polypeptide, mouse, multiscale gene networks, sporadic Alzheimer's disease, sporadic LOAD
Author NameAffiliation
Jean-Vianney Haure-MirandeIcahn School of Medicine at Mount Sinai
Minghui WangDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Ben ReadheadDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Joel T DudleyDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Joel T DudleyDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Robert D BlitzerDepartments of Pharmacological Sciences and Psychiatry, Icahn School of Medicine at Mount Sinai
Eric E SchadtDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Eric E Schadt
Eric E SchadtDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Eric E Schadt
Bin ZhangDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Bin ZhangDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Michelle E EhrlichIcahn School of Medicine at Mount Sinai
Michelle E EhrlichDepartment of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai
Michelle E EhrlichIcahn School of Medicine at Mount Sinai
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