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Paper Details

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.
Cell Rep Med
2
2023
AGC kinase family, BRAF, BRAF-mutant cutaneous melanoma, FAK, GNA11, GNAQ, Gq, PKC, PKN, PRK, ROCK, RhoA, UM, Uveal melanoma, cancer of the eye, darovasertib, mUM, melanoma, metastatic UM, mouse, uveal melanoma
Animals, Drug Evaluation, Preclinical, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Melanoma, Mice, Protein Kinase Inhibitors, Skin Neoplasms, Uveal Neoplasms
Author NameAffiliation
Nadia ArangMoores Cancer Center, University of California San Diego
Simone LubranoMoores Cancer Center, University of California San Diego, USA Department of Pharmacy, University of Pisa
Michele CeribelliDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health
Damiano Cosimo RigiraccioloMoores Cancer Center, University of California San Diego
Robert Saddawi-KonefkaMoores Cancer Center, University of California San Diego
Farhoud FarajiMoores Cancer Center, University of California San Diego
Sydney I RamirezMoores Cancer Center, University of California San Diego
Daehwan KimMoores Cancer Center, University of California San Diego
Frances A TostoDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health
Erica StevensonQuantitative Biosciences Institute (QBI), University of California San Francisco, USA J. David Gladstone Institutes
Yuan ZhouQuantitative Biosciences Institute (QBI), University of California San Francisco, USA J. David Gladstone Institutes
Zhiyong WangMoores Cancer Center, University of California San Diego
Julius BogomolovasUniversity of California San Diego
Alfredo A MolinoloMoores Cancer Center, University of California San Diego
Alfredo A MolinoloMoores Cancer Center, University of California San Diego
Danielle L SwaneyQuantitative Biosciences Institute (QBI), University of California San Francisco, USA J. David Gladstone Institutes
Nevan J Krogan (CM4AI)Quantitative Biosciences Institute (QBI), University of California San Francisco, USA J. David Gladstone Institutes
Jing YangMoores Cancer Center, University of California San Diego
Silvia Coma
Jonathan A Pachter
Andrew E AplinThomas Jefferson University
Dario R AlessiMedical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
Craig J ThomasDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health
Jorge Silvio GutkindMoores Cancer Center, University of California San Diego
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