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Paper Details

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.
Cell Rep
159
2015
-, -FLI1-regulated genes, AP-1, E2F, EWS, Ewing sarcoma, Ewing sarcoma cells, FLI1, RNA, affected mark, enhancer, enhancers, epigenetic cell states, epigenetic promoter signatures, epigenome, histone H3K27, histone deacetylase, oncogene, open chromatin states, promoters, super-enhancers, transcriptome
Acetylation, Cell Line, Tumor, Cellular Reprogramming, Chromatin, Chromosome Mapping, Cluster Analysis, DNA Methylation, Down-Regulation, E2F Transcription Factors, Epigenesis, Genetic, Histone Deacetylase Inhibitors, Histone Deacetylases, Histones, Humans, Oncogene Proteins, Fusion, Promoter Regions, Genetic, Proto-Oncogene Protein c-fli-1, RNA, Small Interfering, RNA-Binding Protein EWS, Sarcoma, Ewing, Transcription Factor AP-1, Transcriptome
Author NameAffiliation
Eleni M TomazouChildren's Cancer Research Institute
Nathan Sheffield (CM4AI)CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Christian SchmidlCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Michael SchusterCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Andreas Sch??neggerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Paul DatlingerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Stefan KubicekCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Christoph BockCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Medical University of Vienna, Austria Max Planck Institute for Informatics
Christoph BockCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Medical University of Vienna, Austria Max Planck Institute for Informatics
Heinrich KovarChildren's Cancer Research Institute, Medical University of Vienna
Heinrich KovarChildren's Cancer Research Institute, Medical University of Vienna
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