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Paper Details

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.
N Engl J Med
114
2021
Author NameAffiliation
Christopher G Hughesthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
John W Devlinthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Antonio Anzuetothe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
James C Jacksonthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Joanna L Stollingsthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Amy L Kiehlthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Hollis R O'Nealthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Mayur B Patelthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Timothy D Girardthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Robert S Dittusthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Gordon R Bernardthe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Eugene Wesley Elythe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
Pratik P Pandharipandethe Center for Health Services Research (C.G.H., R.R.) and Pharmaceutical Services (J.L.S.), Vanderbilt University Medical Center, Education and Clinical Center (R.S.D., Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System - both in Nashville the Neuroscience Institute and Department of Critical Care Medicine, Maine Medical Center, Portland (P.T.M.) the Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, M.S.D.) the Departments of Pharmacy (J.T.S., L.N.B.) and Surgery (J.T.S.) and the Center for Outcomes Research (J.T.S.), Ben Taub Hospital, Baylor College of Medicine (K.K.G.), University of Texas Health, San Antonio (A.A.) and Texas Health Harris Methodist Hospital Fort Worth, Fort Worth (A.S.) - all in Texas the University of Sydney, Royal Prince Alfred Hospital, University of Wisconsin, Baton Rouge General Medical Center and Our Lady of the Lake Regional Medical Center, University of California, Mission Hospital, Ohio State University Wexner Medical Center, Columbus (N.E.B.) and Clinical Research, University of Pittsburgh School of Medicine
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link