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Paper Details

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest.
N Engl J Med
24
2023
Hypercapnia, Out-of-Hospital Cardiac Arrest, carbon dioxide, cardiac arrest, coma, hypercapnia, normocapnia, out, out-of-hospital cardiac arrest, patients
Author NameAffiliation
Yaseen M ArabiAustin Hospital, the Australian and New Zealand Intensive Care Research Centre (G.E., the School of Public Health and Preventive Medicine, Monash University (S.B., Alfred Hospital, University of Melbourne, Royal Melbourne Hospital (A.D., Northern Hospital (A.G.), George Institute for Global Health, Princess Alexandra Hospital, and the School of Medicine, University of Queensland, Brisbane (J.W.) - all in Australia the Clinical Research Centre at St. Vincent's Hospital, University College Dublin, Auckland City Hospital, University of Auckland (R.L.P.), Medical Research Institute of New Zealand (R.L.P., Wellington Regional Hospital (E.L.), Christchurch Hospital, Lund University, Skane University Hospital, Helsingborg Hospital, Helsinki University Hospital and University of Helsinki, Helsinki University Hospital (M. Tiainen) - all in Helsinki the Department of Intensive Care, Hopital Universitaire de Bruxelles-Universite Libre de Bruxelles (F.S.T.), Erasme University Hospital (F.A.) - both in Brussels the Department of Critical Care Medicine, University of Alberta, Aarhus University Hospital and Aarhus University (H.K.), Aarhus University Hospital, Aarhus University (A.M.G.) - all in Aarhus, Centre Hospitalier Universitaire, University of Franche-Comte, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Amsterdam University Medical Centers, University of Oslo (T.O.), Oslo University Hospital-Ulleval (G.O.A., the College of Medicine, King Saud bin Abdulaziz University Hospital for Health Sciences, and King Abdullah International Medical Research Center - all in Riyadh, Tan Tock Seng Hospital, the School of Medicine, National University of Singapore Yong Loo Lin School of Medicine, Nanyang Technological University Lee Kong Chian School of Medicine - all in Singapore (Y.W.C.) the Department of Internal Intensive Medicine, University Medical Center Maribor, Bern University Hospital (M.H.), Bern University Hospital, University of Bern, and the Institute of Intensive Care Medicine, University Hospital of Zurich, University Hospital of Wales, Bristol Royal Infirmary, Royal Victoria Hospital (P.J.M.), and the Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (P.J.M.), Queen Alexandra Hospital
Adam M DeaneAustin Hospital, the Australian and New Zealand Intensive Care Research Centre (G.E., the School of Public Health and Preventive Medicine, Monash University (S.B., Alfred Hospital, University of Melbourne, Royal Melbourne Hospital (A.D., Northern Hospital (A.G.), George Institute for Global Health, Princess Alexandra Hospital, and the School of Medicine, University of Queensland, Brisbane (J.W.) - all in Australia the Clinical Research Centre at St. Vincent's Hospital, University College Dublin, Auckland City Hospital, University of Auckland (R.L.P.), Medical Research Institute of New Zealand (R.L.P., Wellington Regional Hospital (E.L.), Christchurch Hospital, Lund University, Skane University Hospital, Helsingborg Hospital, Helsinki University Hospital and University of Helsinki, Helsinki University Hospital (M. Tiainen) - all in Helsinki the Department of Intensive Care, Hopital Universitaire de Bruxelles-Universite Libre de Bruxelles (F.S.T.), Erasme University Hospital (F.A.) - both in Brussels the Department of Critical Care Medicine, University of Alberta, Aarhus University Hospital and Aarhus University (H.K.), Aarhus University Hospital, Aarhus University (A.M.G.) - all in Aarhus, Centre Hospitalier Universitaire, University of Franche-Comte, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Amsterdam University Medical Centers, University of Oslo (T.O.), Oslo University Hospital-Ulleval (G.O.A., the College of Medicine, King Saud bin Abdulaziz University Hospital for Health Sciences, and King Abdullah International Medical Research Center - all in Riyadh, Tan Tock Seng Hospital, the School of Medicine, National University of Singapore Yong Loo Lin School of Medicine, Nanyang Technological University Lee Kong Chian School of Medicine - all in Singapore (Y.W.C.) the Department of Internal Intensive Medicine, University Medical Center Maribor, Bern University Hospital (M.H.), Bern University Hospital, University of Bern, and the Institute of Intensive Care Medicine, University Hospital of Zurich, University Hospital of Wales, Bristol Royal Infirmary, Royal Victoria Hospital (P.J.M.), and the Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (P.J.M.), Queen Alexandra Hospital
Michael BaileyAustin Hospital, the Australian and New Zealand Intensive Care Research Centre (G.E., the School of Public Health and Preventive Medicine, Monash University (S.B., Alfred Hospital, University of Melbourne, Royal Melbourne Hospital (A.D., Northern Hospital (A.G.), George Institute for Global Health, Princess Alexandra Hospital, and the School of Medicine, University of Queensland, Brisbane (J.W.) - all in Australia the Clinical Research Centre at St. Vincent's Hospital, University College Dublin, Auckland City Hospital, University of Auckland (R.L.P.), Medical Research Institute of New Zealand (R.L.P., Wellington Regional Hospital (E.L.), Christchurch Hospital, Lund University, Skane University Hospital, Helsingborg Hospital, Helsinki University Hospital and University of Helsinki, Helsinki University Hospital (M. Tiainen) - all in Helsinki the Department of Intensive Care, Hopital Universitaire de Bruxelles-Universite Libre de Bruxelles (F.S.T.), Erasme University Hospital (F.A.) - both in Brussels the Department of Critical Care Medicine, University of Alberta, Aarhus University Hospital and Aarhus University (H.K.), Aarhus University Hospital, Aarhus University (A.M.G.) - all in Aarhus, Centre Hospitalier Universitaire, University of Franche-Comte, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Amsterdam University Medical Centers, University of Oslo (T.O.), Oslo University Hospital-Ulleval (G.O.A., the College of Medicine, King Saud bin Abdulaziz University Hospital for Health Sciences, and King Abdullah International Medical Research Center - all in Riyadh, Tan Tock Seng Hospital, the School of Medicine, National University of Singapore Yong Loo Lin School of Medicine, Nanyang Technological University Lee Kong Chian School of Medicine - all in Singapore (Y.W.C.) the Department of Internal Intensive Medicine, University Medical Center Maribor, Bern University Hospital (M.H.), Bern University Hospital, University of Bern, and the Institute of Intensive Care Medicine, University Hospital of Zurich, University Hospital of Wales, Bristol Royal Infirmary, Royal Victoria Hospital (P.J.M.), and the Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (P.J.M.), Queen Alexandra Hospital
Rinaldo BellomoAustin Hospital, the Australian and New Zealand Intensive Care Research Centre (G.E., the School of Public Health and Preventive Medicine, Monash University (S.B., Alfred Hospital, University of Melbourne, Royal Melbourne Hospital (A.D., Northern Hospital (A.G.), George Institute for Global Health, Princess Alexandra Hospital, and the School of Medicine, University of Queensland, Brisbane (J.W.) - all in Australia the Clinical Research Centre at St. Vincent's Hospital, University College Dublin, Auckland City Hospital, University of Auckland (R.L.P.), Medical Research Institute of New Zealand (R.L.P., Wellington Regional Hospital (E.L.), Christchurch Hospital, Lund University, Skane University Hospital, Helsingborg Hospital, Helsinki University Hospital and University of Helsinki, Helsinki University Hospital (M. Tiainen) - all in Helsinki the Department of Intensive Care, Hopital Universitaire de Bruxelles-Universite Libre de Bruxelles (F.S.T.), Erasme University Hospital (F.A.) - both in Brussels the Department of Critical Care Medicine, University of Alberta, Aarhus University Hospital and Aarhus University (H.K.), Aarhus University Hospital, Aarhus University (A.M.G.) - all in Aarhus, Centre Hospitalier Universitaire, University of Franche-Comte, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Amsterdam University Medical Centers, University of Oslo (T.O.), Oslo University Hospital-Ulleval (G.O.A., the College of Medicine, King Saud bin Abdulaziz University Hospital for Health Sciences, and King Abdullah International Medical Research Center - all in Riyadh, Tan Tock Seng Hospital, the School of Medicine, National University of Singapore Yong Loo Lin School of Medicine, Nanyang Technological University Lee Kong Chian School of Medicine - all in Singapore (Y.W.C.) the Department of Internal Intensive Medicine, University Medical Center Maribor, Bern University Hospital (M.H.), Bern University Hospital, University of Bern, and the Institute of Intensive Care Medicine, University Hospital of Zurich, University Hospital of Wales, Bristol Royal Infirmary, Royal Victoria Hospital (P.J.M.), and the Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast (P.J.M.), Queen Alexandra Hospital
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link