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Paper Details

PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2<sup>V617F</sup>-Mutant MPN.
Cancer Discov
53
2020
E2F targets, E2F1, Gene, JAK, JAK2V617F, JAK2V617F-Mutant MPN, JAK2V617F/MPLW515L MPN models, MPLW515L, MPN, PRMT5, fibrosis, hepatosplenomegaly, leukocyte, leukocytosis, myelofibrosis, myeloproliferative neoplasm, polycythemia vera, primary MPN cells, primary samples, splenomegaly
Author NameAffiliation
Richard KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center
Richard KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center
Kristian HelinCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center
Kristian Helin
Kristian HelinUniversity of Copenhagen
Kristian HelinThe Novo Nordisk Foundation of Stem Cell Research (Danstem), University of Copenhagen
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