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Paper Details

Tracking the Evolution of Non-Small-Cell Lung Cancer.
N Engl J Med
1495
2017
Author NameAffiliation
Richard MitterFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
David A MooreFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
Fiona BlackhallFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
Dean A FennellFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
Apostolos NakasFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
Stefan C DentroFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
John Le QuesneFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
Peter Van LooFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
Charles SwantonFrom the Cancer Research UK Lung Cancer Centre of Excellence (M.J.-H., Good Clinical Laboratory Practice Facility, University College London (UCL) Experimental Cancer Medicine Centre (H.L.L., UCL Cancer Institute, Francis Crick Institute, Royal Marsden Hospital (S. Turajlic), UCL Hospitals, UCL Respiratory, UCL (S.M.J.), North Middlesex University Hospital (G.A.), Royal Free Hospital (S. Khan), and UCL Cancer Research UK and Cancer Trials Centre (N.I., University of Leicester (D.A.M., Glenfield Hospital (A.N., and the Medical Research Center Toxicology Unit (J.L.Q.), the Institute of Cancer Studies, University of Manchester (F.B.), the Christie Hospital (F.B., University Hospital of South Manchester, and Cancer Research UK Manchester Institute (C.D.), Birmingham Heartlands Hospital, Queen Elizabeth Hospital (P.T., and Institute of Immunology and Immunotherapy, University of Birmingham (G.M.), Aberdeen University Medical School and Aberdeen Royal Infirmary, Barnet and Chase Farm Hospitals, Princess Alexandra Hospital, St. Luke's Cancer Centre, Ashford and St. Peters' Hospitals, Velindre Hospital (J.F.L.), University Hospital Llandough, University Hospital of Wales, and Cardiff University (R.A.), and Wellcome Trust Sanger Institute, and Big Data Institute, University of Oxford, Oxford (S.D.) - all in the United Kingdom the Center for Biological Sequence Analysis, Technical University of Denmark, Boston Children's Hospital and Harvard Medical School, Semmelweis University, Hungary (Z.S.) Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, University of Leuven
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Datasets

ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link
ClinicalTrials.govClinicalTrials.gov, a registry and results database of of privately and publicly funded clinical studies conducted around the world, is operated by the U.S. National Library of Medicine (NLM). Structured study information is provided, voluntarily or to meet legal and policy requirements, by the sponsor or investigator responsible for the research. NLM does not verify the scientific validity or relevance of the submitted information beyond a limited quality control review for apparent errors, deficiencies, or inconsistencies.Link